Take the Menopause Symptom Quiz
Understand the story behind your symptoms.
Get solutions for optimal midlife health.

Menopause, a life-changing transition for women, is not just about hot flashes and night sweats. An often-overlooked aspect of this life stage is the onset or exacerbation of mood disorders, such as anxiety and depression. According to the American Psychological Association, about 20% of women will experience depression at some point during menopause, while anxiety symptoms can be even more prevalent. What lies at the heart of these mood changes, and how can Bioidentical Hormone Replacement Therapy (BHRT) be a potential game-changer?
Menopause induces a decrease in essential hormones like estrogen and progesterone, which have been shown to interact with neurotransmitters responsible for mood regulation, such as serotonin and dopamine. A study published in “Archives of Women’s Mental Health” reveals that declining estrogen levels can impact serotonin receptors, thereby influencing mood and potentially contributing to anxiety and depression.
Take a validated quiz to learn more about your menopause symptoms.
Numerous reports and studies have showcased the potential benefits of BHRT for mood stabilization. For example, a landmark study in “JAMA Psychiatry” followed postmenopausal women with severe depressive disorders and found that those who underwent estradiol therapy experienced a significant reduction in depressive symptoms compared to those on a placebo.
Another compelling case involves a 52-year-old woman who was experiencing not just vasomotor symptoms but also crippling anxiety. After undergoing personalized BHRT, her anxiety levels decreased substantially, enhancing her overall quality of life. These real-life cases underline the importance of individualized assessment and treatment plans.
Understanding the link between hormones and mood disorders during menopause is vital for effective treatment. Bioidentical Hormone Replacement Therapy can offer relief for many, but it is crucial to consult with healthcare providers for an individualized treatment plan based on individual risk factors and symptoms.
Functional Medicine Practitioner & Wellness Expert
Dr. Manna Semby, ND, IFMCP, MSCP, is a naturopathic and functional medicine doctor based in San Diego, California. She is the only doctor in the San Diego area who is both a Menopause Society Certified Practitioner and certified in the ReCODE 2.0 Protocol for preventing and reversing Alzheimer’s disease and dementia. She is also is a MoCA certified administrator. With over ten years in medicine, Dr. Manna has helped many women reverse early stages of cognitive decline through comprehensive brain, bone, metabolic, and midlife hormone medical care. She draws on years of clinical training and ongoing professional development to translate complex medical insights into practical, real-world precision medicine guidance.
Learn more about the Stay Sharp Program.
Discover how Dr. Manna has been helping women understand their risk, identify the factors influencing their brain health, and take meaningful action to protect their future.
This website uses cookies to enhance your experience. Some are essential for site functionality, while others help us analyze and improve your usage experience. Please review your options and make your choice.
If you are under 16 years old, please ensure that you have received consent from your parent or guardian for any non-essential cookies.
Your privacy is important to us. You can adjust your cookie settings at any time. For more information about how we use data, please read our privacy policy. You may change your preferences at any time by clicking on the settings button below.
Note that if you choose to disable some types of cookies, it may impact your experience of the site and the services we are able to offer.
Some required resources have been blocked, which can affect third-party services and may cause the site to not function properly.
This website uses cookies to enhance your browsing experience and ensure the site functions properly. By continuing to use this site, you acknowledge and accept our use of cookies.